The Mouse Gene Map.

Knowledge about the laboratory mouse (Mus) genome is far more advanced than that of any other experimental mammal (Figure 1). The first mammalian autosomal linkage group was identified in the mouse (Haldane and others 1915). Since 1915, genetic mapping in the mouse has progressed with increasing rapidity each decade, with nearly 25,000 genes and DNA loci (segments) on the current map. This article provides a brief history of the mouse mapping efforts, highlights specific advances in the last 30 years that led to rapid increments in map growth, describes the methods used to generate the mouse map, and shows the status of the map as of January 1998.